"Four eyes" is a pejorative nickname for people who wear glasses.
How It's Used
"Nina [Simone] and I were alone. Me, a skinny, pimple-faced, Beatle-mopped, four-eyed timid teen. She, a regal African queen reincarnate with a larger-than-life persona; the essence of exquisite eccentricity; a high priestess returned from other lives to cajole, remind, sing the blues, and stand for her people."
—David Nathan, liner notes for "Nina Simone: Anthology: The Colpix Years," Rhino Records, 1996, p. 9.